Inhibition of neutrophil activity improves cardiac function after cardiopulmonary bypass
نویسندگان
چکیده
منابع مشابه
Inhibition of nitric oxide synthesis improves left ventricular contractility in neonatal pigs late after cardiopulmonary bypass.
BACKGROUND Following neonatal open heart surgery a nadir occurs in left ventricular function six to 12 hours after cardiopulmonary bypass. Although initiated by intraoperative events, little is known about the mechanisms involved. OBJECTIVE To evaluate the involvement of nitric oxide in this late phase dysfunction in piglets. DESIGN Piglets aged 2 to 3 weeks (4-5 kg) underwent cardiopulmona...
متن کاملTemporary epicardial left ventricular and biventricular pacing improves cardiac output after cardiopulmonary bypass
BACKGROUND To evaluate, with different pacing modes, acute changes in left ventricular systolic function, obtained by continuous cardiac output thermodilution in various subsets of patients undergoing cardiopulmonary bypass surgery. Increments of mean arterial pressure and cardiac output were considered the end point. METHODS Fifty cases electively submitted to cardiac surgery were analyzed. ...
متن کاملCarvedilol-Enriched Cold Oxygenated Blood Cardioplegia Improves Left Ventricular Diastolic Function After Weaning From Cardiopulmonary Bypass.
OBJECTIVES To investigate whether adding carvedilol, a nonselective β- and selective α1-receptor blocking agent with antioxidant properties, to oxygenated blood cardioplegia improves myocardial function after weaning from bypass. DESIGN A randomized controlled study. SETTING A university laboratory. PARTICIPANTS Twenty anesthetized pigs, Norwegian Landrace. INTERVENTIONS On cardiopulmon...
متن کاملEffects of FP15, a peroxynitrite decomposition catalyst on cardiac and pulmonary function after cardiopulmonary bypass.
OBJECTIVE Peroxynitrite, a toxic nitrogen species, has been implicated in the development of ischemia/reperfusion injury. The aim of the present study was to investigate the effects of the potent peroxynitrite decomposition catalyst, FP15, on myocardial, endothelial, and pulmonary function in an experimental model of cardioplegic arrest and extracorporal circulation. METHODS Twelve anesthetiz...
متن کاملModified ultrafiltration after cardiopulmonary bypass in pediatric cardiac surgery.
BACKGROUND Cardiopulmonary bypass in children results in considerable water retention, especially in neonates and small infants. Dilution of plasma proteins increases water loss into the extravascular compartments. Excessive total body water may prolong ventilatory support and may contribute to a prolongation of intensive care convalescence. After discontinuation of cardiopulmonary bypass, modi...
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ژورنال
عنوان ژورنال: Journal of Inflammation
سال: 2007
ISSN: 1476-9255
DOI: 10.1186/1476-9255-4-21